2-phenylbenzo[f][1,3]benzoxazole-4,9-dione CAS#:63388-44-3_上海皓元生物医药科技有限公司

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2-phenylbenzo[f][1,3]benzoxazole-4,9-dione

CAS号	63388-44-3
规格	5mg10mg	纯度	98%
货号	HY-15757	货期	3天
品牌	Medchemexpress	库存	需咨询
规格	5mg10mg
纯度	98%
货号	HY-15757
货期	3天
品牌	Medchemexpress
库存	---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价：￥2167.00 元/5mg

立即询盘

货号	品牌	纯度	规格	参考价	货期
HY-15757	Medchemexpress	98%	5mg10mg	￥2167.00元/5mg	3天

产品详情

详细信息(中文)：
SJB2-043是C527的类似物，是新型的泛素特异蛋白酶USP1抑制剂，IC50为544nM。

详细信息(英文)：
产品描述：SJB2-043SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. _x000D_ IC50 Value: 0.544 uM (USP1) [1]_x000D_ Target: USP1_x000D_ Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed by immunoblotting with anti-USP1 or anti-HA antibodies. Consistent with our previous studies and the most recent studies by Piatkov et al (24, 31, 33), USP1 in the untreated cells was detected on western blot as a doublet; full length USP1 and an auto-cleaved USP1 with only N-terminus. The Ub-USP1 conjugates were generated in the untreated cell lysates and were detected by an increase in molecular weight of USP1. However, the formation of the Ub-USP1 conjugate was inhibited by the addition of SJB2-043. Ub-aldehyde, a potent known nonspecific DUB inhibitor, caused a complete loss of USP1-Ub-VS conjugates in this competition assay. SJB2-043 inhibited the Ub-VS labeling of a limited number of endogenous DUB enzymes. In 公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商，产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。 MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、专利； MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足最新的科研需求；数千种产品在上海有充足备货，24-48小时内送达客户；大量产品提供免费试用装；已为全球多个知名企业、院校构建各种定制型化合物库。产品链接：www.medchemexpress.cn/sjb2-043.html