eletriptan hydrobromide CAS#:177834-92-3_上海皓元生物医药科技有限公司

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eletriptan hydrobromide

CAS号	177834-92-3
规格	5mg10mg	纯度	98%
货号	HY-A0010	货期	3天
品牌	Medchemexpress	库存	需咨询
规格	5mg10mg
纯度	98%
货号	HY-A0010
货期	3天
品牌	Medchemexpress
库存	---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价：￥600.00 元/5mg

立即询盘

货号	品牌	纯度	规格	参考价	货期
HY-A0010	Medchemexpress	98%	5mg10mg	￥600.00元/5mg	3天

详细信息(英文)：
产品描述：Eletriptan (hydrobromide)Eletriptan HBr is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively._x000D_ IC50 value: 0.82 nM/3.14 nM (5-HT1B/5-HT1D, Ki) [1]_x000D_ Target: 5-HT1B/5-HT1D _x000D_ in vitro: [3H]Eletriptan has a total number of binding sites (Bmax) of 2478 fmol/mg and 1576 fmol/mg for 5-HT1B and 5-HT1D, respectively. [3H]Eletriptan has a significantly faster association rate (K(on) 0.249/min/nM) than [3H]sumatriptan (K(on) 0.024/min/nM) and a significantly slower off-rate (K(off) 0.027/min compared to 0.037/min for [3H]sumatriptan) [1]. Eletriptan induces concentration-dependent contractions of meningeal artery, coronary artery, and saphenous vein. The potency of Eletriptan is higher in meningeal artery than in coronary artery (86-fold) or saphenous vein (66-fold). The predicted contraction by Eletriptan (40 mg and 80 mg) and sumatriptan (100 mg) at free C(max) observed in clinical trials is similar in meningeal artery [2]._x000D_ in vivo: Eletriptan (

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物理化学性质
英文名	1H-Indole, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-, hydrobromide (1:1)
中文名	依来曲普坦氢溴酸盐
CAS号	177834-92-3	溶解性	---
分子量	463.43894	熔点	169-171ºC
密度	---	沸点	633.9ºC at 760 mmHg