Vinflunine Tartrate CAS#:1201898-17-0_上海皓元生物医药科技有限公司

买产品
克难题
找技术
猎聘
发定制
产学研对接
查百科
资讯
入驻智库
发布供需

LOADING IMAGES

Vinflunine Tartrate

CAS号	1201898-17-0
规格	5mg10mg	纯度	98%
货号	HY-B0628A	货期	3天
品牌	Medchemexpress	库存	需咨询
规格	5mg10mg
纯度	98%
货号	HY-B0628A
货期	3天
品牌	Medchemexpress
库存	---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价：￥1252.00 元/5mg

立即询盘

货号	品牌	纯度	规格	参考价	货期
HY-B0628A	Medchemexpress	98%	5mg10mg	￥1252.00元/5mg	3天

产品详情

详细信息(中文)：
Vinflunine酒石酸盐是种独特的长春花生物碱，能干扰微管蛋白和有丝分裂。

详细信息(英文)：
产品描述：Vinflunine (Tartrate)Vinflunine Tartrat is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity._x000D_ Target: Microtubule/Tubulin_x000D_ The major effects of Vinflunine on dynamic instability are a slowing of the microtubule growth rate, an increase in growth duration, and a reduction in shortening duration. The effects of Vinflunine on the readmilling rate is examined by following [3H]GTP incorporation into MAP-rich microtubules, and the IC50 is 0.42 μM [1]. Vinflunine induced mitotic accumulation with IC50 with 18.8 nM, which decreases the centromere dynamicity by 44% and increases the time centromeres spent ina paused state by 63% [2]. Treatment of Vinflunine induces a rapid change in endothelial cell shape: cells retracts and assumes a rounded morphology. Mean IC50 values are 9.9 × 10-5 M × 10-5 M for fibronectin and 5.0× 10-5 M × 10-5 M for type IV collagen. A short 4 hours exposure of endothelial cells to Vinflunine at 10-8