osthol CAS#:484-12-8_上海皓元生物医药科技有限公司

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osthol

CAS号	484-12-8
规格	250mg1g	纯度	98%
货号	HY-N0054	货期	3天
品牌	Medchemexpress	库存	需咨询
规格	250mg1g
纯度	98%
货号	HY-N0054
货期	3天
品牌	Medchemexpress
库存	---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价：￥410.00 元/250mg

立即询盘

货号	品牌	纯度	规格	参考价	货期
HY-N0054	Medchemexpress	98%	250mg1g	￥410.00元/250mg	3天

产品详情

详细信息(中文)：
Osthole(NSC 31868, Osthol)是类香豆素衍生物，能刺激成骨细胞的增殖与分化，有抗炎效果。

详细信息(英文)：
产品描述：OstholeOsthole(NSC 31868, Osthol), a coumarin-like derivative extracted from Chinese herbs, has been shown to stimulate osteoblast proliferation and differentiation, anti-inflamatory._x000D_ IC50 value:_x000D_ Target: Anticancer; anti-inflammatory_x000D_ in vitro: Following treatment of cells with osthole at 2.5, 5, 10 and 20 μg/mL, the NF-κB and TGF-β1 expressions were dose-dependently decreased, while the expressions of PPARα/γ and MMP-2/9 were dose-dependently increased. After the cells were preincubated with PPARα antagonist (MK886) or/and PPARγ antagonist (GW9662), the inhibitions of osthole on the NF-κB and TGF-β1 expressions were decreased or completely halted and the increment of osthole on the MMP-2/9 expressions were also decreased or completely cancelled [1]. Osthole activated Wnt/beta-catenin signaling, increased Bmp2 expression, and stimulated osteoblast differentiation. Targeted deletion of the beta-catenin and Bmp2 genes abolished the stimulatory effect of Osthole on osteoblast differentiation. 公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商，产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。 MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、专利； MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足最新的科研需求；数千种产品在上海有充足备货，24-48小时内送达客户；大量产品提供免费试用装；已为全球多个知名企业、院校构建各种定制型化合物库。产品链接：www.medchemexpress.cn/osthole.html