详细信息(中文)： 中文名称:吡罗昔康倍他环糊精 中文别名:吡罗昔康-β-环糊精 CAS No:96684-39-8 分子式:C57H83N3O39S 沸点:1541.2°Cat760mmHg 闪光点:885.9°C (1)药效学:本品具有镇痛、抗炎及解热作用。本品通过抑制环氧酶使组织局部前列腺素的合成减少及抑制白细胞的趋化性和溶酶体酶的释放而起到药理作用。本品治疗关节炎时的镇痛、消肿等疗效与吲哚美辛、阿司匹林、萘普生相似。但由于本品抑制环氧酶-2所需的浓度高于抑制环氧酶-1的浓度，因此胃肠道的不良反应较多。
(2)药动学:口服吸收好。食物可降低吸收速度，但不影响吸收总量。血浆蛋白结合率高达90%以上。经肝脏代谢。半衰期平均为50小时(30~86小时)，肾功能不全患者半衰期延长。由于半衰期较长，一次给药即可维持24小时的血药浓度相对稳定，多次给药易致蓄积。一次服药20mg，3~5小时血药浓度达峰值，血药有效浓度为1.5~2μg/ml。血药稳定浓度在开始治疗后7~12天方能达到。66%自肾脏排泄，33%自粪便排泄，内有<5%为原形物。 详细信息(英文)： Chinese name: Piroxicam Piroxicam. Chinese alias: Piroxicam. Molecular Formula: C57H83N3O39S boiling point: 1541.2 Cat760mmHg Flash Point: 885.9 C1 PHARMACODYNAMICS: This product has analgesic, anti-inflammatory and antipyretic effects. This product through the inhibition of cyclooxygenase to reduce local tissue prostaglandin synthesis and inhibit leukocyte chemotaxis and lysosomal enzyme release and play a pharmacological role. It is similar to Indomethacin, aspirin and Naproxen in pain relief and detumescence. However, the concentration of cyclooxygenase-2 is higher than that of cyclooxygenase-1, so there are more adverse reactions in gastrointestinal tract. 2 PHARMACOKINETICS: Oral Absorption. Food may reduce the absorption rate, but does not affect the total absorption. The protein binding rate is over 90% . Transhepatic metabolism. The average half-life was 50 hours and 30-86 hours. The half-life of patients with renal insufficiency was prolonged. Because of the Long half-life, a drug can maintain a 24-hour blood concentration is relatively stable, multi-drug easy accumulation. The blood concentration reached its peak in 3ー5 hours after taking 20mg once, and the effective concentration was 1.5ー2 G / ml. The blood drug stable concentration reached 7 ~ 12 days after treatment. 66% excreted from the kidney, 33% excreted from the stool, and 5% was the prototype.