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2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile

2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile

CAS号 65678-07-1
规格 5mg10mg
纯度 98%
货号 HY-10253
货期 3天
品牌 Medchemexpress
库存 ---
注意:请务必与卖家联系核实单价库存,以确保您的资金安全及交易顺利。
参考价: ¥884.00 元/5mg
货号 品牌 纯度 规格 参考价 货期
HY-10253 Medchemexpress 98% 5mg10mg ¥884.00元/5mg 3天

产品详情

详细信息(中文):
AG-1024 (Tyrphostin)能抑制IGF-1R自磷酸化,IC50为7 μM,而对IR的IC50则为57 μM。
详细信息(英文):
产品描述:AG1024AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM._x000D_ IC50 value: 7 uM (IGF-1R autophosphorylation); 57 uM (IR) [1]_x000D_ Target: IGF-1R; IR_x000D_ in vitro: AG-1024 blocks the IGF-1 receptor and IR autophosphorylation with IC50 of 7 μM and 57 μM, respectively. AG-1024 also inhibits the receptor tyrosine kinase activity towards exogenous substrates (TKA) with IC50 values of 18 μM and 80 μM, respectively [1]. Human breast cancer cell line MCF-7 exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Examination of Tyrphostin AG 1024 effects on radiation response demonstrated a marked enhancement in radiosensitivity and amplification of radiation-induced apoptosis [2]. AG-1024 significantly inhibits melanoma cell proliferation with an IC50 of

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英文名 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile
中文名 ---
CAS号 65678-07-1 溶解性 ---
分子量 305.17000 熔点 ---
密度 1.42g/cm3 沸点 379.8ºC at 760 mmHg

商家信息

上海皓元生物医药科技有限公司

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联系人:皓元 点击这里给我发消息

号码一: 400****

号码二: 021****

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  • 公司类型:研发型
  • 成立时间:2009-03-17
  • 所在地区:上海市市辖区
  • 注册资本:300万元
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