CCT 241533 hydrochloride CAS#:1431697-96-9_上海皓元生物医药科技有限公司

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CCT 241533 hydrochloride

CAS号	1431697-96-9
规格	2mg5mg	纯度	98%
货号	HY-14715B	货期	3天
品牌	Medchemexpress	库存	需咨询
规格	2mg5mg
纯度	98%
货号	HY-14715B
货期	3天
品牌	Medchemexpress
库存	---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价：￥930.00 元/2mg

立即询盘

货号	品牌	纯度	规格	参考价	货期
HY-14715B	Medchemexpress	98%	2mg5mg	￥930.00元/2mg	3天

产品详情

详细信息(中文)：
CCT241533盐酸盐是丝氨酸/苏氨酸Chk2抑制剂，IC50为3 nM，在1 uM浓度下对其它激酶的交叉反应极低。

详细信息(英文)：
产品描述：CCT241533 (hydrochloride)CCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a panel of kinases at 1 uM._x000D_ IC50 Value: 3 nM_x000D_ Target: Chk2_x000D_ CCT241533 bound to CHK2 in the ATP pocket. This compound inhibits CHK2 with an IC(50) of 3 nmol/L and shows minimal cross-reactivity against a panel of kinases at 1 μmol/L. CCT241533 blocked CHK2 activity in human tumor cell lines in response to DNA damage, as shown by inhibition of CHK2 autophosphorylation at S516, band shift mobility changes, and HDMX degradation. CCT241533 did not potentiate the cytotoxicity of a selection of genotoxic agents in several cell lines. However, this compound significantly potentiates the cytotoxicity of two structurally distinct PARP inhibitors. Clear induction of the pS516 CHK2 signal was seen with a PARP inhibitor alone, and this activation was abolished by CCT241533, implying that the potentiation of PARP inhibitor cell killing by CCT241533 was due to inhi 公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商，产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。 MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、专利； MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足最新的科研需求；数千种产品在上海有充足备货，24-48小时内送达客户；大量产品提供免费试用装；已为全球多个知名企业、院校构建各种定制型化合物库。产品链接：www.medchemexpress.cn/cct241533-hydrochloride.html