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4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid

4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid

CAS号 102121-60-8
规格 5mg10mg
纯度 98%
货号 HY-10475
货期 3天
品牌 Medchemexpress
库存 ---
注意:请务必与卖家联系核实单价库存,以确保您的资金安全及交易顺利。
参考价: ¥700.00 元/5mg
货号 品牌 纯度 规格 参考价 货期
HY-10475 Medchemexpress 98% 5mg10mg ¥700.00元/5mg 3天

产品详情

详细信息(中文):
AM580(Am-580; Ro 40-6055; NSC608001; CD336)最初合成作为RARα激动剂。
详细信息(英文):
产品描述:AM580AM580(Am-580; Ro 40-6055; NSC608001; CD336) is a stable retinobenzoic derivative originally synthesized as a RARα agonist._x000D_ IC50 value:_x000D_ Target: RARα agonist_x000D_ in vitro: AM580 is a powerful inducer of granulocytic maturation in NB4, an APL-derived cell line, and in freshly isolated APL blasts. After treatment of APL cells with AM580 either alone or in combination with granulocyte colony-stimulating factor (G-CSF), the compound induces granulocytic maturation, as assessed by determination of the levels of leukocyte alkaline phosphatase, CD11b, CD33, and G-CSF receptor mRNA, at concentrations that are 10- to 100-fold lower than those of ATRA necessary to produce similar effects [1]. _x000D_ in vivo: A dose of 0.3mg/kg/day of Am580, was tested by treating 10 FVB mice for 4 months; no overt toxicity was found in liver, lungs, kidney, and spleen [2]. Treatment of MMTV-Myc mice with the RARα-selective agonist Am580 led to significant inhibition of mammary tumor growth (~90%, P

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英文名 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid
中文名 4-[(5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基)甲酰氨基]苯甲酸
CAS号 102121-60-8 溶解性 ---
分子量 351.43900 熔点 265-267℃
密度 1.154g/cm3 沸点 461ºC at 760 mmHg

商家信息

上海皓元生物医药科技有限公司

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  • 公司类型:研发型
  • 成立时间:2009-03-17
  • 所在地区:上海市市辖区
  • 注册资本:300万元
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产品:4-[(5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基)甲酰氨基]苯甲酸