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(R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide

(R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide

CAS号 1133432-49-1
规格 2mg5mg
纯度 98%
货号 HY-15427
货期 3天
品牌 Medchemexpress
库存 ---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价： ￥2333.00 元/2mg
立即询盘
货号 品牌 纯度 规格 参考价 货期
HY-15427 Medchemexpress 98% 2mg5mg ￥2333.00元/2mg 3天

产品详情

详细信息(中文)：
GDC-0834是高效BTK抑制剂，在体外生化和细胞实验中IC50分别为5.9和6.4 nM。
详细信息(英文)：
产品描述：GDC-0834GDC-0834 is a potent and selective BTK inhibitor with in vitro IC50s of 5.9 and 6.4 nM in biochemical and cellular assays, respectively._x000D_ IC50 value: 5.9 nM/6.4 nM(biochemical/cellular assay) [1]_x000D_ Target: BTK_x000D_ in vitro: GDC-0834 inhibited BTK with an in vitro IC(50) of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC(50) of 1.1 and 5.6 μM in mouse and rat, respectively [1]._x000D_ in vivo: Administration of GDC-0834 (30-100 mg/kg) in a rat collagen-induced arthritis (CIA) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology [1]. GDC-0834 exhibited low clearance in PXB chimeric mice with humanized liver. Uncertainty in human pharmacokinetic prediction and high interest in a BTK inhibitor for clinical evaluation prompted an investigational new drug strategy, in which GDC-0834 was rapidly advanced to a single-dose human clinical trial. GDC-0834 plasma concentrations in humans were below the limit of quantitation (

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英文名 (R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide
中文名 ---
CAS号 1133432-49-1 溶解性 ---
分子量 596.74200 熔点 ---
密度 --- 沸点 ---

商家信息

上海皓元生物医药科技有限公司logo

上海皓元生物医药科技有限公司

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  • 公司类型：研发型
  • 成立时间：2009-03-17
  • 所在地区：上海市市辖区
  • 注册资本：300万元
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