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4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid

4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid

CAS号 402473-54-5
规格 2mg5mg
纯度 98%
货号 HY-50901
货期 3天
品牌 Medchemexpress
库存 ---
注意:请务必与卖家联系核实单价库存,以确保您的资金安全及交易顺利。
参考价: ¥850.00 元/2mg
货号 品牌 纯度 规格 参考价 货期
HY-50901 Medchemexpress 98% 2mg5mg ¥850.00元/2mg 3天

产品详情

详细信息(中文):
ONO-AE3-208(AE 3-208)是EP4拮抗剂,能抑制前列腺癌细胞侵袭,迁移和转移。
详细信息(英文):
产品描述:ONO-AE3-208ONO-AE3-208(AE 3-208) is an EP4 antagonist; suppresses cell invasion, migration, and metastasis of prostate cancer._x000D_ IC50 value:_x000D_ Target: EP4 _x000D_ EP4 over-expressing LNCaP was established, and their cell invasiveness was compared with the control LNCaP (LNCaP/mock). The in vitro cell proliferation, invasion, and migration of these cells were examined under different concentrations of ONO-AE3-208. An in vivo bone metastatic mouse model was constructed by inoculating luciferase expressing PC3 cells into left ventricle of nude mice. Their bone metastasis was observed by bioluminescent imaging with or without ONO-AE3-208 administration. The EP4 mRNA expression levels were higher in PC3 than in LNCaP, and EP4 over-expression of LNCaP cells enhanced their cell invasiveness. _x000D_ Arachidonic acid caused dose-dependent dilation of the attached Af-Art (from 8.6 ± 1.2 to 15.3 ± 0.7 μm; P

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英文名 4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid
中文名 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
CAS号 402473-54-5 溶解性 ---
分子量 404.43400 熔点 ---
密度 1.3 沸点 662.36ºC at 760 mmHg

商家信息

上海皓元生物医药科技有限公司

营业执照已审核 企业已认证

联系人:皓元 点击这里给我发消息

号码一: 400****

号码二: 021****

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  • 公司类型:研发型
  • 成立时间:2009-03-17
  • 所在地区:上海市市辖区
  • 注册资本:300万元
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产品:4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸