Exatecan mesylate CAS#:169869-90-3_上海皓元生物医药科技有限公司

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Exatecan mesylate

CAS号	169869-90-3
规格	1mg5mg	纯度	98%
货号	HY-13631A	货期	3天
品牌	Medchemexpress	库存	需咨询
规格	1mg5mg
纯度	98%
货号	HY-13631A
货期	3天
品牌	Medchemexpress
库存	---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价：￥5115.00 元/1mg

立即询盘

货号	品牌	纯度	规格	参考价	货期
HY-13631A	Medchemexpress	98%	1mg5mg	￥5115.00元/1mg	3天

产品详情

详细信息(中文)：
Exatecan(DX-8951)甲磺酸盐是拓扑异构酶I抑制剂喜树碱的合成类似物，增加了其水溶性和抗肿瘤活性，降低了毒性。

详细信息(英文)：
产品描述：Exatecan (Mesylate)Exatecan Mesylate (DX-8951) is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself._x000D_ IC50 value:_x000D_ Target: topoisomerase I_x000D_ Exatecan was given as i.v. infusion over 30 min at a dose of 0.5mg/m2 every day for five consecutive days, repeated every 21 days. Seventy-four percentage of cycles could be given without dose or schedule modification. The main toxicity was haematotoxicity with grade 3/4 neutropenia in 49%, grade 3/4 thrombocytopenia in 23%, and grade 3/4 anaemia in 15% of patients, respectively [1]. The most common drug-related toxicity was neutropenia. Non-hematologic toxicities were mostly mild to moderate; the most common were nausea, vomiting and anorexia. Plasma concentrations of DX-8951 (the anhydrous form of DX-8951f) were well described using a linear 2-compartment PK model. All concentrations and dose events were simult 公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商，产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。 MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、专利； MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足最新的科研需求；数千种产品在上海有充足备货，24-48小时内送达客户；大量产品提供免费试用装；已为全球多个知名企业、院校构建各种定制型化合物库。产品链接：www.medchemexpress.cn/exatecan-mesylate.html