Palifosfamide CAS#:31645-39-3_上海皓元生物医药科技有限公司

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Palifosfamide

CAS号	31645-39-3
规格	5mg10mg	纯度	98%
货号	HY-14798	货期	3天
品牌	Medchemexpress	库存	需咨询
规格	5mg10mg
纯度	98%
货号	HY-14798
货期	3天
品牌	Medchemexpress
库存	---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价：￥2325.00 元/5mg

立即询盘

货号	品牌	纯度	规格	参考价	货期
HY-14798	Medchemexpress	98%	5mg10mg	￥2325.00元/5mg	3天

产品详情

详细信息(中文)：
Palifosfamide (ZIO-201)是ifosfamide (IFOS)的活性代谢物，为DNA烷化剂，可作用于软组织肉瘤（STS）。

详细信息(英文)：
产品描述：PalifosfamidePalifosfamide (ZIO-201) is the functional active metabolite of ifosfamide (IFOS), a bi-functional DNA alkylator being investigated as a potential therapy for the treatment of soft tissue sarcoma (STS). _x000D_ IC50 Value: 0.5-1.5mg/ml [1]_x000D_ Target: DNA alkylator_x000D_ in vitro: Palifosfamide lysine was cytotoxic against all the cell lines tested with the IC(50) ranging from 0.5 to 1.5 microg/ml except for OS222, which had an IC(50) of 7 microg/ml [1]._x000D_ in vivo: Dose response, route and schedule of administration, and interaction with docetaxel or doxorubicin were investigated in NCr-nu/nu mice bearing established orthotopic mammary MX-1 tumor xenografts. Oral activity was investigated in P388-1 leukemia in CD2F1 mice. Oral and intraperitoneal bioavailabilities were compared in Sprague-Dawley rats. Stabilized palifosfamide administered by optimized regimens suppressed MX-1 tumor growth (P